tag:blogger.com,1999:blog-26666124.post5149015955493646492..comments2024-03-18T03:28:36.581-04:00Comments on Shrink Rap: VEGF: the New antidepressantUnknownnoreply@blogger.comBlogger10125tag:blogger.com,1999:blog-26666124.post-53394598655250990092009-10-02T23:08:01.546-04:002009-10-02T23:08:01.546-04:00As a newly diagnosed cancer patient, I am very int...As a newly diagnosed cancer patient, I am very interested in the question about antidepressants VEGF and cancer. I have been taking Cymbalta for the last 4 years and now I suddenly have cancer, liver hemangiomas, and a proliferation of non-cancerous colon polyps--all conditions driven by VEGF. <br />Has anybody seen research that directly looked at whether Cymbalta or other antidepressant usage could fuel cancer angiogenesis? <br /><br />VEGF and anti-depressants <br />http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1838655 <br /><br />liver hemangiomas <br />http://www.ncbi.nlm.nih.gov/pubmed/18814928 <br /><br />intestinal polyps <br />http://mcr.aacrjournals.org/content/5/12/1296/F6.expansion <br /><br />breast cancer <br />http://www.researchvegf.com/researchvegf/tumors/breast/index.mAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-26666124.post-37696690174793693052008-01-02T17:09:00.000-05:002008-01-02T17:09:00.000-05:00Isn't VEGF associated with cancer? As in increase...Isn't VEGF associated with cancer? As in increased levels are associated with certain cancers and a lot of the biological *mab drugs aim to block VEGF?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-26666124.post-11254394658902652972007-04-07T21:46:00.000-04:002007-04-07T21:46:00.000-04:00Hey, MWWK, I'm now picture hippo-neurons hippity h...Hey, MWWK, I'm now picture hippo-neurons hippity hopping around in my brain . . . . <BR/><BR/>Dancing hipponeurons . . . ala the dancing hippoballet in Fantasia . . . <BR/><BR/>Woohoo, it's like being high, without the drugs (never done drugs, but when describing one particularly manic episode, my ologist said I was high; when I described that I quit feeling guilty about feeling so frickin' AWESOME and just laid back and enjoyed it and floated away.)Sarebearhttps://www.blogger.com/profile/09208596053319110470noreply@blogger.comtag:blogger.com,1999:blog-26666124.post-57564834446953018732007-04-07T10:16:00.000-04:002007-04-07T10:16:00.000-04:00Ah, thanks Roy. Trust me, there are stupid questi...Ah, thanks Roy. Trust me, there are stupid questions. (Such as, from my brother, "My auto emergency kit comes wiht flares; can you help me think of something fun to do with them? Um... how about keeping them in your car in case you need them?")<BR/><BR/>It looks like the answer is "Maybe not, but maybe...". :) I was just thinking that if the hippocampus in people with depression is normal, then making more neurons grow there may have unforseen negative long-term effects. But if, the hippocampus is not-quite-normal, then additional neuronal growth might be exactly what people need.<BR/><BR/>Or maybe the actual lesion is somewhere else, and making people grow more hippocampal neurons (hipponeurons?) allows their brains to compensate in different ways.Midwife with a Knifehttps://www.blogger.com/profile/04309579302399381913noreply@blogger.comtag:blogger.com,1999:blog-26666124.post-36000974039896308262007-04-07T02:43:00.000-04:002007-04-07T02:43:00.000-04:00If you want synthesized poop, try some of those jo...If you want synthesized poop, try some of those journals and such made out of processed Elephant dung.<BR/><BR/>Yeah, OT. I think this (not the dung, but the subject of the post) is interesting, although I still feel FAT everytime I see the hippo part in there. Lol.Sarebearhttps://www.blogger.com/profile/09208596053319110470noreply@blogger.comtag:blogger.com,1999:blog-26666124.post-33921798127847269922007-04-07T00:04:00.000-04:002007-04-07T00:04:00.000-04:00Midwife (no question is stupid)...European J Neuro...Midwife (no question is stupid)...<BR/><A HREF="http://www.blackwell-synergy.com/links/doi/10.1046/j.0953-816x.2001.01784.x" REL="nofollow">European J Neurosci 2001</A>: No difference in postmortem hippocampi of depr and nondepr humans.<BR/><BR/><A HREF="http://www.jneurosci.org/cgi/content/abstract/19/12/5034" REL="nofollow">J Neurosci 1999</A>: Duration of depression correlated with hippocampal volume loss.<BR/><BR/><A HREF="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4S-4DNPBG9-7&_user=10&_coverDate=11%2F01%2F2004&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=b982be161a8587419d0d60cffcaac101" REL="nofollow">Biol Psychiatr 2004</A>: Reduced hippocampal volume, and increased cell density, in depressed subjects.<BR/><BR/>Uhh, I don't know the answer but these are places to start. Let us know if someone can synthesize the latest poop.Royhttps://www.blogger.com/profile/08735111026336537653noreply@blogger.comtag:blogger.com,1999:blog-26666124.post-25097671756928087602007-04-06T21:25:00.000-04:002007-04-06T21:25:00.000-04:00Cool BEANS!Wait, beans are a legume, not a veg.Coo...Cool BEANS!<BR/><BR/>Wait, beans are a legume, not a veg.<BR/><BR/>Cool CARROTS! (Happy Easter!)<BR/><BR/>Or, as my dd has taken to saying w/no disrespect intended . . .<BR/><BR/>Happy Keister!Sarebearhttps://www.blogger.com/profile/09208596053319110470noreply@blogger.comtag:blogger.com,1999:blog-26666124.post-76428572232224803482007-04-06T19:03:00.000-04:002007-04-06T19:03:00.000-04:00I like seeing stuff like this. It gives me hope a...I like seeing stuff like this. It gives me hope about neuronal regrowth and neuroplasticity. You're right, it may be a long way down the road but at least people are still looking and not giving up.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-26666124.post-77638014143096922872007-04-06T11:16:00.000-04:002007-04-06T11:16:00.000-04:00Stupid question: Do depressed people have reduced ...Stupid question: Do depressed people have reduced number of neurons or neuronal death in their hippocampusus (hippocampi?)Midwife with a Knifehttps://www.blogger.com/profile/04309579302399381913noreply@blogger.comtag:blogger.com,1999:blog-26666124.post-85483233855100234562007-04-06T09:10:00.000-04:002007-04-06T09:10:00.000-04:00Sounds like this might be in some trials in the ne...Sounds like this might be in some trials in the near future. I know quite a bit about new treatments and trials. You are right that this might be an option many years from now. A long, slow process is ahead. And when the word "speculate" is in any article, the process of getting it from an idea to the patient takes even more time.Anonymousnoreply@blogger.com